Sinkona Indonesia Lestari, PT ( PT. SIL), Manufacturer Quinine and Derivatives from Indonesia

Sinkona Indonesia Lestari, PT (PT. SIL) located at Ciater - Subang, about 30 km or 45 minutes from Bandung West Java and located at the plateau of 700 meters above sea level. Operating in quinine and its derivatives manufacturing with production capacity output 150 tons per year. Raw material or cinchona bark production process is supplied continuously by PT. Perkebunan Nusantara VIII (PTPN VIII) West Java, a state owned company which its business core is in agriculture including cinchona bark plantation.
 
Since its establishment in 1991 PT. SIL has exported the products world wide and currently is one of the biggest quinine manufacturer in the world with customers segment in pharmaceutical, beverage, and resolving agent manufacturers.

And to fulfill international product standards required by the customers and relevant authorities, all of PT. SIL products are manufactured under Good Manufacturing Practice (GMP) and already approved by the United States Food and Drug Administration DMF license number 9631 and 9632 and also another quality assurance system and control.

 

For more information about Sinkona Indonesia Lestari, PT visit http//sinkona-indonesia.com

Cinchona Alkaloids from Cinchona Bark

Cinchona alkaloids  are widely  used  in the    pharmaceutical    and   chemical industry.  The  most popular compound Quinine  is   a    valuable   antimalarial agent  and  muscle relaxant  compound for more than 100  years,  its  „pseudo enantiomer“  Quinidine   is  used as  a cardiac   depressant   (antiarrhythmic). Furthermore   Quinine  is  also  an   im-important bitter agent  in the beverage (soft drink) industry. Cinchonine    and    Cinchonidine  are widespread   resolving   agents   particu-larly for  acids.  Cinchona  alkaloids  and their modified  derivatives are significant  chiral catalysts in asymmetric syntheses for example Corey enolalkylation & sharp-less dihydroxylation. One aspect of their application as ligand accelerated catalyst  (LAC) is their bidentate nature which allows optimal binding to transition metals.
Per year several hundred tons of Cinchona alkaloids are extracted from the bark of the Cinchona ledgeriana and Cinchona Succirubra. Of all known alkaloids they are the mostly used compounds for commercial purposes. cinchonine    R = OMe    Quinine R = H         Cinchonidine Quinine and other Cinchona alkaloids are extracted from the bark of the Cinchona tree, which is mainly cultivated in Afrika, Latin-Amerika and Indonesia R = OMe    Quinidine R =

Nonmedical Uses of Quinine

In some areas, nonmedical use of quinine is regulated. For example, in the United States and Germany, quinine is limited to between 83 and 85 parts per million.

Beverages

Quinine is a flavour component of tonic water and bitter lemon. On the soda gun behind many bars, tonic water is designated by the letter "Q" representing quinine. According to tradition, the bitter taste of antimalarial quinine tonic led British colonials in India to mix it with gin, thus creating the gin and tonic cocktail, which is still popular today in many parts of the world, especially the UK, United States, Canada, Australia, and New Zealand. In France, quinine is an ingredient of an apéritif known as quinquina or "Cap Corse". In Italy, the traditional flavoured wine Barolo Chinato is infused with quinine and local herbs and is served as a digestif. In Canada and Italy, quinine is an ingredient in the carbonated chinotto beverages Brio and San Pellegrino chinotto. In Scotland, the company A.G. Barr uses quinine as an ingredient in the carbonated and caffeinated beverage Barr's Irn-Bru. In the United Kingdom, Australia, New Zealand, South Africa and Egypt, quinine is an ingredient in Schweppes and other brands of Indian Tonic Water "mixer" drink called 'Dry Lemon'. Schweppes and a few other drinks makers also produce Bitter Lemon, a pale green mixer drink containing quinine. In Uruguay and Argentina, quinine is an ingredient of a Pepsico Inc. tonic water named Paso de los Toros. In Denmark, it is used as an ingredient in the carbonated sports drink Faxe Kondi made by Royal Unibrew.

Scientific

Because of its relatively constant and well-known fluorescence quantum yield, quinine is used in photochemistry as a common fluorescence standard. The UV absorption peaks around 350 nm (in UVA). Fluorescent emission peaks at around 460 nm (bright blue/cyan hue).
Quinine (and quinidine) are used as the chiral moiety for the ligands used in Sharpless asymmetric dihydroxylation.
The bark of Remijia contains 0.5–2% of quinine. The bark is cheaper than bark of Cinchona, and as it has an intense taste, it is used for making tonic water.

Other

Quinine is sometimes used as a cutting agent in street drugs such as cocaine and heroin.
Quinine is used as a treatment for Cryptocaryon irritans (commonly referred to as white spot, crypto or marine ich) infection of marine aquarium fish.

Product List

1. Quinine Hydrochloride
2. Quinine Dihydrochloride
3. Quinine Sulfate
4. Quinine Base Anhydrous
5. Cinchonine
6. Cinchonidine
7. Quinidine Base
8. Quinine Sulfate